Curriculum vitae


Contact 

Eric Edward Bryant, PhD

Email / Github / Twitter
ResearchGate / ORCID / LinkedIn


Education 

2011—2018
PhD, Columbia University
Department: GSAS Biological Sciences
Thesis: Systems genetics of DNA damage tolerance — cisplatin, RAD5 & CRISPR-mediated nonsense
Mentor: Rodney Rothstein
Co-Mentor: Alberto Ciccia
Committee: Songtao Jia, Elizabeth Miller & Matthew Weitzman
Keywords: Systems genetics / Genetic interaction networks / Landscape enrichment analysis / Synthetic lethality / DNA replication, recombination & repair / Chromosome mobility / CRISPR iSTOP / Bioinformatics / R statistical programming
2006—2009
BS, University of California Los Angeles
Department: UCLA Microbiology, Immunology & Molecular Genetics
2004—2006
West Valley College
Department: WVC Biology

Employment 

2009—2011
Gene Oracle, Research Assistant
Role: De-novo gene synthesis & degenerate codon library construction. Pipeline management and development.
Manager: Shannon Phan

Software 

2019
screenmill R package: capture, annotate, quantify, review and analyze time-series colony growth. This package was used for colony quantification and interaction analysis in Bryant et al. 2019. A nice example analysis using screenmill can be found in Figure 1D.
2017
iSTOP R package: design guides to introduce stop codons with CRISPR-mediated base editors. This package was written to facilitate guide design for Billon et el. 2017. iSTOP can be configured to design guides to generate any desired missense mutation using any hypothetical base editor in any genome with annotated coding sequence coordinates.

Teaching 

2013
Columbia University, Teaching Assistant for Molecular Biology
Professors: Songtao Jia & Ron Prywes
2012
Columbia University, Teaching Assistant for Cell Biology
Professors: Elizabeth Miller & Chloë Bulinski

Awards 

2018
Departmental distinction for PhD dissertation defense
2017—2018
TL1 NIH training grant, clinical and translational research
2016—2017
T32 NIH training grant, cancer biology
2013—2015
T32 NIH training grant, biological sciences
2013
James Howard McGregor award (student with unusual promise as a teacher of zoology)

Publications 

Lead contribution

2019-09-26
Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability.
Bryant EE, Šunjevarić I, Berchowitz L, Rothstein R, Reid RJD.
Nucleic Acids Research. 2019 Sep 26;47(17):9144—9159
PMID: 31350889PMCID: PMC6753471DOI: 10.1093/nar/gkz631
2019-01-09
Systems genetics of DNA damage tolerance – Cisplatin, RAD5 & CRISPR-mediated nonsense.
Bryant EE.
Columbia University.
DOI: 10.7916/d8-k1d0-kb09
2017-09-21
CRISPR-mediated base editing enables efficient disruption of eukaryotic genes through induction of STOP codons.
Billon P*, Bryant EE*, Joseph SA, Nambiar TS, Hayward SB, Rothstein R, and Ciccia A.
Molecular Cell. 2017 Sep 21;67(6):1068—1079.e4
PMID: 28890334PMCID: PMC5610906DOI: 10.1016/j.molcel.2017.08.008
*co-first authors

Supporting contribution

2019-10-01
DNA damage triggers increased mobility of chromosomes in G1 phase cells.
Smith MJ, Bryant EE, Joseph FJ, Rothstein R.
Molecular Biology of the Cell. 2019 Oct 1;30(21):2620—2625
PMID: 31483739PMCID: PMC6761769DOI: 10.1091/mbc.E19-08-0469
2018-09-01
Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint.
Smith MJ, Bryant EE, Rothstein R.
Genes & Development. 2018 Sep 1;32(17-18):1242—1251
PMID: 30181361PMCID: PMC6120718DOI: 10.1101/gad.317966.118
2016-10-01
A synthetic dosage lethal genetic interaction between CKS1B and PLK1 is conserved in yeast and human cancer cells.
Reid RJD, Du X, Šunjevarić I, Rayannavar V, Dittmar J, Bryant E, Maurer M, and Rothstein R.
Genetics. 2016 Oct 1;204(2):807—819
PMID: 27558135PMCID: PMC5068864DOI: 10.1534/genetics.116.190231

Downloads 

CV (.pdf)  /   References (.bib)